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SALINOMYCIN - Avhandlingar.se

Synthetic strategies for modification of each of the directly accessible functional groups of salinomycin are presented and the resulting library of analogues was investigated to establish structure–activity relationships, both with respect to cytotoxicity and phenotype selectivity in breast cancer cells. 20‐O‐Acylated derivatives stand out by exhibiting both improved selectivity and activity. 2016-04-28 2017-02-10 Salinomycin with antibacterial and anticoccidial activities is a commercial polyether polyketide widely used in animal husbandry as a food additive. Malonyl-CoA (MCoA), methylmalonyl-CoA (MMCoA), and ethylmalonyl-CoA (EMCoA) are used as extension units in its biosynthesis 2017-02-15 Salinomycin. 2 Product Results. | Match Criteria: Product Name, Property, Description. Empirical Formula (Hill Notation): C42H70O11.

Salinomycin structure

1 Treatment of 5 mg For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from PDBe, to allow us to map Pfam domains onto UniProt three-dimensional structures.The table below shows the sequences and Pfam domains that correspond to this structure. To the best of our knowledge until now no information on the ability of salinomycin to form complexes with Cd(II), Pb(II) and Hg(II) has been published. In the present paper we report for the first time the preparation and the structure characterization of salinomycin complexes with ions of … 2011-09-09 Search results for salinomycin751005300310411 at Sigma-Aldrich. Compare Products: Select up to 4 products. *Please select more than one item to compare chemBlink provides information on suppliers of Salinomycin (CAS # 53003-10-4) If submitting your inquiry to a single supplier, click Inquire for this suplier. If submitting your inquiry to multiple suppliers, .

The parent hydroxamic acid, salinomycin-NHOH, forms both Structure, properties, spectra, suppliers and links for: Salinomycin sodium.

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Salinomycin. Molecular Formula C 42 H 70 O 11; Average mass 750.999 Da; Monoisotopic mass 750.491821 Da; ChemSpider ID 2342058 1973-01-01 Salinomycin sodium | C42H69NaO11 | CID 23703990 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. Synthetic strategies for modification of each of the directly accessible functional groups of salinomycin are presented and the resulting library of analogues was investigated to establish structure–activity relationships, both with respect to cytotoxicity and phenotype selectivity in breast cancer cells.

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S4526. from Streptomyces albus, ≥98% (HPLC) Sigma-Aldrich.

CAS Number: 53003-10-4. S4526. from Streptomyces albus, ≥98% (HPLC) Sigma-Aldrich.
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(2R)-2- ( (5S)-6- {5- [ (10S,12R)-2- ( (6S,5R)-5-Ethyl-5-hydroxy-6-methylperhydro-2H-pyran-2-yl)-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro [4.1.5.3]pentadec-13-en-9-yl] (1S,2S,3S,5R)-2-hydroxy-1,3-dimethyl-4-oxoheptyl}-5-methylperhydro-2H-pyran-2-yl)butanoic acid. Molecular Structure. properties of salinomycin is highlighted by a significant loss of activity by modifications directly interfering with either of the two primary ion coordinating motifs in salinomycin, the C11 ketone and the C1 carboxylate. Introduction Phenotypic heterogeneity within tumors has emerged as a key Total Structure Weight: 97.58 kDa ; Atom Count: 6732 ; Modelled Residue Count: 856 ; Deposited Residue Count: 934 ; Unique protein chains: 1 (A) Chemical structure of salinomycin. (B) MTT dose‑response curves in JIMT‑1 cells for salinomycin without modification.

Salinomycin (CHEBI:80025) has role animal growth promotant (CHEBI:82655) Salinomycin (CHEBI:80025) has role potassium ionophore (CHEBI:88227) Salinomycin (CHEBI:80025) is a polyketide (CHEBI:26188) Salinomycin (CHEBI:80025) is a spiroketal (CHEBI:72600) 13 Salinomycin Sodium O O O OH O H H O OH H O OH O HO H Salinomycin C42H70O11 MW: 751.0 CAS No.: 53003-10-4 (salinomycin), 55721-31-8 (salinomycin Na) [Summary of salinomycin sodium] Salinomycin is a polyether antibiotic obtained by the incubation of Streptomyces albus and has the chemical structure shown above. PDF | Salinomycin diastereoisomers and their benzoylated derivatives were synthesized and evaluated with both antiproliferative activities and | Find, read and cite all the research you need on IC50: 7.7, 13.7 and 10.4 μM for HepG2, SMMC-7721 and BEL-7402 cell line, respectively (after 24h treatment) Salinomycin (Sal), which is a polyether ionophore antibiotic from Streptomyces albus, has been proven to be able to kill different types of human The ionophore salinomycin selectively targets cancer stem cells.
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Salinomycin has been shown by Piyush Gupta et al. of the Massachusetts Institute of Technology and the Broad Institute to kill breast cancer stem cells in mice at least 100 times more effectively than the anti-cancer drug paclitaxel.

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Sultamicillin Base, Sultamicillin Tosylate EP, BP Tillverkare

These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists. Structure. Valinomycin is a dodecadepsipeptide, that is, it is made of twelve alternating amino acids and esters to form a macrocyclic molecule. The twelve carbonyl groups are essential for the binding of metal ions, and also for solvation in polar solvent. The isopropyl and methyl groups are responsible for solvation in nonpolar solvents. Identification. Name.

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Mol. formula: C42H70O11 The parent hydroxamic acid, salinomycin-NHOH, forms both inclusion complexes and well-defined electroneutral complexes with potassium and sodium cations via 1,3-coordination by the hydroxamic acid moiety to the metal ion. Salinomycin. 2 Product Results. | Match Criteria: Product Name, Property, Description. Empirical Formula (Hill Notation): C42H70O11. Molecular Weight: 751.00.

salinomycin och monensin är fortfarande tillåtna men föreslås av Soil compaction processes and their effects on the structure of arable soils and the. Using a structure estimation method based on molecular connectivity indices(1), the Koc of salinomycin can be estimated to be 6050(SRC). According to a classification scheme(2), this estimated Koc value suggests that salinomycin is expected to be immobile in soil. Structure, properties, spectra, suppliers and links for: Salinomycin, 53003-10-4. Salinomycin is the key compound in the pharmaceutical company Verastem's efforts to produce an anti-cancer-stem-cell drug. Use in agriculture. Salinomycin is used in chicken feed as a coccidiostat.